Nobel Prize Worthy Vibrotactile Technology
The 2021 Nobel Prize in Physiology or Medicine was awarded to David Julius and Ardem Patapoutian to honor their discovery of the fundamental sensors of temperature and pressure based on Piezo Mechanotransduction Ion Channels.
Nobel Prize Lecture: How do you feel? The molecules that sense touch (34:27)
How It Works
The technology inside the Super Patch has uniquely arranged ridges that look like a QR code, when these ridges touch our skin, our cells transmit unique signals that interact with our body’s nervous system.
Every physical, emotional and mental function has a specific neuro-code or “message.”
In the real world QR codes send messages through the internet, The Super Patch pattern QR Code sends messages through our nervous system and each patch has a unique code and a unique message.
The brain and nervous system decodes the message immediately, and a waterfall of wellness responses happen, from more energy to enhanced balance and quality of life
From Skin To Brain
"I have been updating my hubby’s journey with Parkinson’s over the last 3 yrs and what Voxxlife products have done for him. The Freedom patch has been a lifesaving. Most with Parkinson’s have pain issues which seem to intensify due to the disease. The Freedom patch has given him a new lease in life. With all the struggles he’s has to endure this patch has given him the relief needed to go through his days with less pain. Another issue that affects those with Parkinson’s is depression, and anxiety. His days were fill worriedness that he slept his days away. It’s been weeks since wearing the Peace patch and a huge difference has occurred. His days are filled with laughter and peace. He no longer sleeps his days away. He always seems to find something to do. Our next step is to use the Flow patch which will help with cognitive decline. These patches, Liberty, Defend, Freedom and Peace have given him the wellness he needs daily to function with his Parkinson’s. I’m grateful daily for Jay and his team at Voxxlife for the development of these amazing products. Thank you. ❤️"
The Super Science
Touch is a complicated sense that results from many different types of mechanical stimuli: Pressure, texture, vibrations, and more.
Even when a child is born the bond with mother is solidified with touch.
As a species, the need for human touch is vital. Just look at what isolation did during the pandemic to peoples health.
Different types of nerve cells transmit distinct types of sensory information, such as gentle touch and vibration.
Our sense of touch is sensitive enough to detect even the movement of a single hair.
The skin is the largest sensory organ and it can transmit signals to the brain through Piezoelectricity.
Now, these forces can be tapped into using Vibrotactile (Vibration) Technology to harness the power of nature in order to maximize health.
Tapping into the "Propeller of Energy"
Vibrotactile (Vibration) Technology: Feeling Sound
If you’ve set your phone to vibrate, you’ve experienced vibrotactile feedback. Put simply: vibrotactile feedback is feeling sounds.
“If you want to find the secrets of the universe, think in terms of energy, frequency and vibration.” — Nikola Tesla
Sound is a form of mechanical energy that consists of back-and-forth motion of a material. Usually, we think of sound waves travelling through air, but they can also travel through almost any other material, including human skin.
In a term known as Cymatics, sound can produce specific geometric wave patterns. Vibrotactile Technology is similar to Cymatics, but in reverse. Geometric patterns are used to produce signals that are detected through the skin and transmitted to the brain.
Galileo famously stated that our Universe is a “grand book” written in the language of mathematics. We often forget that music, physics and chemistry studies share the geometry of nature, best illustrated by frequency, vibration and energy. Where there is matter, there is geometry.
"If frequency determines physiology, which it does, then if you can control the geometry, you can control the physiology." — Joseph Phillips
A Pacinian Corpuscle (aka the world’s smallest onion)
We have a specialized type of receptor in certain parts of our skin called a Pacinian Corpuscle that is tuned to detect these geometric patterns. These little onion-like receptors are exquisitely sensitive to geometric vibratory patterns.
Merkel cells are found at the base of the outermost layer of your skin (epidermis). Merkel cells are connected to the nerve endings in the skin that are responsible for the sense of touch. Merkel cells in the basal epidermis of the skin store serotonin, which they release in response to pressure (piezoelectric effects). Merkel cells make synaptic contacts with somatosensory afferent nerve fibers. The somatosensory system is the network of neural structures in the brain and body that produce the perception of touch (haptic perception), as well as temperature (thermoception), body position (proprioception), and pain. Afferent nerve fibers are axons (nerve fibers) of sensory neurons that carry sensory information from sensory receptors to the central nervous system. A touch or painful stimulus, for example, creates a sensation in the brain only after information about the stimulus travels there via afferent nerve pathways. Somatosensation begins when mechanotransduction in the skin sense physical stimuli such as pressure on the skin. Activation of these receptors leads to activation of peripheral sensory neurons that convey signals to the spinal cord as patterns of action potentials. Sensory information is then processed locally in the spinal cord to drive reflexes, and is also conveyed to the brain for conscious perception of touch and proprioception.
Merkel Nerve Ending
Merkel nerve endings are mechanoreceptors, a type of sensory receptor, that are found in the layers of the skin and hair follicles. They are nerve endings and provide information on mechanical pressure, position, and deep static touch features, such as shapes and edges. They are tactile sensors in the business of mechanotransduction. They encode surface features of touched objects into perception, but also have to do with proprioception. Merkel cells transduce tactile stimuli / mechanical forces into signals, which trigger serotonin release; they have also been called a "serotonergic synapse". Like the cells responsible for the mechanotransduction in hearing, Merkel cells transduce mechanical forces into excitatory signals via ion conductance on mechanosensitive channels, of which Piezo2 is the Merkel cell's primary mechanosensor. They fire fastest, when small points indent the skin, and fire at a low rate on slow curves or flat surfaces. Merkel cell nerve endings are primary sites of tactile transduction and Piezo2 ion channel is the Merkel cell mechanical transducer. Piezo2 transduces tactile stimuli into Ca2+-action potentials in Merkel cells, which drive Aβ-afferent nerve endings to fire slowly adapting impulses.
Proprioception is the sense of self-movement, force, and body position. Proprioceptors transfer the mechanical state of the body into patterns of neural activity. Members of the transient receptor potential family of ion channels have been found to be important for proprioception. Piezo genes, especially Piezo2, is essential for mechanosensitivity in some proprioceptors. Proprioception, a sense vital for rapid and proper body coordination, can be impaired as a result of genetic malfunctions, disease, viral infections, and injuries. For instance, individuals with joint hypermobility have chronic impairments to proprioception. Moreover, proprioception may be chronically impaired in physiological aging and numerous other diseases. The impact of losing the sense of proprioception on daily life is perfectly illustrated when Ian Waterman stated, "What is an active brain without mobility". Proprioception is what allows someone to learn to walk in complete darkness without losing balance. Kind of like your "6th Sense" related to self-awareness or self-consciousness.
Interoception is the collection of senses providing information to the organism about the internal state of the body. This can be both conscious and subconscious. It encompasses the brain's process of integrating signals relayed from the body into specific subregions. This is important for maintaining homeostatic conditions in the body and, potentially, facilitating self-awareness. Misrepresentations of internal states, or a disconnect between the body's signals and the brain's interpretation and prediction of those signals, have been suggested to underlie conditions such as anxiety, depression, panic disorder, anorexia nervosa, bulimia nervosa, posttraumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), alexithymia, somatic symptom disorder, and illness anxiety disorder. This relates to all physiological tissues that relay a signal to the central nervous system about the current state of the body. Like a heartbeat or growling stomach. Interoceptive signals are transmitted to the brain via multiple pathways including somatosensory pathways from the skin.
Mechanotransduction describes processes by which mechanical forces are converted into biological responses. Mechanotransduction is essential for physiological functions including the sense of touch. The basic mechanism of mechanotransduction involves converting mechanical signals into electrical or chemical signals. In this process, a mechanically gated ion channel makes it possible to cause a change in specialized sensory cells and sensory neurons. The stimulation of a mechanoreceptor causes ion channels to produce a transduction current that changes the membrane potential of the cell. Skin is the largest human organ and has constant intense contact with the environment. Today it is known that mechanical forces influence the growth, shape and behavior of nearly every cell, tissue and organ of the human body. Cells can sense and respond to a wide range of external chemical and physical signals and, consequently, change their morphology, dynamics and behavior. As such, mechanotransduction has become a topic of increasing awareness and consequently scientific interest in many fields of research. Through the study of mechano-immunology, it is now increasing understood that mechanical cues are just as important as biochemical cues for determining immune system function.
Piezoelectricity is the electric charge that accumulates in biological matter such as bone, DNA, and various proteins in response to applied mechanical stress. Piezoelectricity is literally translated as electricity as a result of pressure. In a nutshell, piezoelectricity is the process of converting mechanical energy into electrical energy or vice versa.
As we move through the world, we sense, respond, and adapt to many types of mechanical forces. These processes, broadly referred to as mechanosensation, include the conscious perception of touch (an aspect of somatosensation), the effortless control of our posture (proprioception), and the unconscious regulation of physiological functions such as breathing and heart rate (interoception). In each of these cases, force activates specialized cells called mechanoreceptors that generate and transmit signals to the nervous system and body. Piezo ion channels are sensors of mechanical forces and mediate a wide range of physiological mechanotransduction processes. They are the actual PROPELLERS that move energy from the zero point energy field into biological matter. Piezo genes in the body are the PROPELLERS of ENERGY. In other words, energy and electric signals, sometimes referred to zero point energy, flow through the PIEZO genes to transmit signals into your body. Now, these forces can be tapped into using this technology to harness the power of nature for maximizing health.
Piezo1 and Piezo2 genes are required for touch sensing. They have been mentioned as being our "6th Sense Genes". Piezo2 is typically found in cell types that respond to physical touch, such as previously mentioned Merkel cells, and is thought to regulate light touch response. Piezo2 is indeed an essential mechanotransducer for touch, proprioception, and interoception. Piezo2 expression in both dorsal root ganglia (DRG) sensory neurons and Merkel cells is required for the harmless touch sensation.
Keratin is the key structural material making up scales, hair, nails, feathers, horns, claws, hooves, and the outer layer of skin. Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile information to sensory neurons. Keratinocytes, which constitute >95% of the cells in the epidermis, are innately sensitive to mechanical force, are capable of releasing a wide array of neuroactive factors. Thus, keratinocyte activity is critical for normal sensory neuron and behavioral responses to mechanical stimuli. Piezo1 mediates keratinocyte mechanical sensitivity. Keratinocyte activation and subsequent signaling functions in concert with sensory neurons and other cutaneous end organ structures to amplify normal touch sensation.
Dorsal Root Neurons
The function of the dorsal root ganglia is to transmit sensory information from the peripheral nervous system to the central nervous system. A Dorsal Root Ganglion (DRG) emerges from the dorsal root of the spinal nerves. They carry sensory messages from various receptors (i.e., touch receptors) at the periphery towards the central nervous system for a response. They are responsible for conveying various sensory stimuli, including pain, touch, vibration, proprioception, and temperature, from the peripheral nervous system to the central nervous system. The dorsal root ganglia generate chronic pain due to their role in creating and transmitting pain signals.
Over the last decade, the DRG is now recognized as a viable option for neuromodulation therapy and is also considered a viable option in treating chronic pain. The DRG participates in sensory transduction and modulation, including pain transmission. The dorsal root ganglia are active in potentiating pain, including chronic pain. The dorsal root ganglia contain many small, unmyelinated, nociceptive C-fiber cells involved in pain reception. The C-fiber cells contain substance P and calcitonin gene-related peptide (CGRP), two substances implicated in inflammation and neuropathic pain. Additionally, pain impulses have been shown to originate in the dorsal root ganglia themselves, making them a good target for the treatment of chronic pain.
Piezo1 is primarily expressed in nonsensory tissues, whereas Piezo2 is predominantly found in sensory tissues, including dorsal root ganglion (DRG) neurons.
In conclusion, these "Piezo Patches" tap into the very nature and structure of the universe for the ultimate "6th Sense Enhancement."